Selected Publications
Al-Zain, A. M., Nester, M. R., Ahmed, I., & Symington, L. S. (2023). Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism. Nature communications, 14(1), 7020.
Kimble, M. T., Johnson, M. J., Nester, M. R., & Symington, L. S. (2023). Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation. eLife, 12, e84322.
Gnügge, R., Reginato, G., Cejka, P., Symington, L. S. (2023) Sequence and chromatin features guide DNA double-strand break resection initiation. Molecular Cell.
Marie, L., Symington, L.S. (2022) Mechanism for inverted-repeat recombination induced by a replication fork barrier. Nat Commun 13, 32.
Stivison, E. A., Young, K. J., and Symington, L. S. (2020) Interstitial telomere sequences disrupt break-induced replication and drive formation of ectopic telomeres. Nucleic Acids Research.
Gnugge, R. and Symington, L.S. (2020) Efficient DNA double-strand break formation at single or multiple defined sites in the Saccharomyces cerevisiae genome. Nucleic Acids Research.
Donnianni, R.A., Zhou, Z., Lujan, S.A., Al-Zain, A., Garcia, V., Glancy, E., Burkholder, A.B., Kunkel, T.A., and Symington, L.S. (2019) DNA Polymerase Delta Synthesizes Both Strands during Break-Induced Replication. Mol. Cell 76: 371-381.
Tai-Yuan Yu, Michael T. Kimble, and Symington, L.S. (2018) Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection. Proc. Natl. Acad. Sci. U.S.A. 115 (51) E11961-E11969.
Gnugge, R., Oh, J. and Symington, L.S. (2018) Processing of DNA double-strand breaks in yeast. Methods Enzymol. 600: 1-24.
Gnugge, R. and Symington, L.S. (2017) Keeping it real: MRX-Sae2 clipping of natural substrates. Genes Dev.31: 2311-2312.
Ruff, P., Donnianni, R.A., Glancy, E., Oh, J. and Symington, L.S. (2016) RPA stabilization of single-stranded DNA is critical for break-induced replication. Cell Rep. 17: 3359-3368.
Ciccia, A. and Symington, L.S. (2016) Stressing out about RAD52. Mol. Cell 64: 1017-1019.
Symington, L.S. (2016) Mechanism and regulation of DNA end resection in eukaryotes. Crit. Rev. Biochem. Mol. Biol. 51: 195-212.
Oh, J., Al-Zain, A., Cannavo, E., Cejka, P. and Symington, L.S. (2016) Xrs2 dependent and independent functions of the Mre11-Rad50 complex. Mol. Cell 64: 405-415.
Deng, S.K., Yin, Y., Petes, T.D. and Symington, L.S. (2015) Mre11-Sae2 and RPA collaborate to prevent palindromic gene amplification. Mol. Cell 60: 500-508.
Chen, H., Donnianni, R.A., Handa, N., Deng, S.K., Oh, J., Timashev, L.A., Kowalczykowski, S.C. and Symington, L.S. (2015) Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling. Proc. Natl. Acad. Sci. U.S.A. 112: E1880-1887.
Deng, S.K., Chen, H. and Symington, L.S. (2015) Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity. Bioessays 37: 305-313.
Symington, L.S., Rothstein, R. and Lisby, M. (2014) Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae. Genetics 198: 795-835.
Symington, L.S. (2014) DNA repair: Making the cut. Nature 514: 39-40.
Lee, A.H., Symington, L.S. and Fidock, D.A. (2014) DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum. Microbiol Mol. Biol. Rev. 78: 469-486.
Deng, S.K., Gibb, B., Almeida, M.J., Greene, E.C. and Symington, L.S. (2014) RPA antagonizes microhomology-mediated repair of DNA double-strand breaks. Nature Struct. Mol. Biol. 21: 405-412.
Eissler, C.L., Mazon, G., Powers, B.L., Savinov, S.N., Symington, L.S. and Hall, M.C. (2014) The Cdk/Cdc14 module controls activation of the Yen1 Holliday junction resolvase to promote genome stability. Mol. Cell 54:80-93.
Stafa, A., Donnianni, R.A., Timashev, L.A., Lam, A.F. and Symington, L.S. (2014) Template switching during break-induced replication is promoted by the Mph1 helicase in Saccharomyces cerevisiae. Genetics 196:1017-1028.
Mazon, G. and Symington, L.S. (2013) Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates. Mol. Cell 52: 63-74.
Donnianni, R.A. and Symington, L.S. (2013) Break-induced replication occurs by conservative DNA synthesis. Proc. Natl. Acad. Sci. U.S.A. 110: 13475-13480.
Chen, H., Lisby, M. and Symington, L.S. (2013) RPA coordinates DNA end resection and prevents formation of DNA hairpins. Mol. Cell 50: 589-600.
Mazon, G., Lam, A.F., Ho, C.K., Kupiec, M. and Symington, L.S. (2012) The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats. Nature Struct. Mol. Biol. 9: 964-971.
Klein, H.L. and Symington, L.S. (2012) Sgs1-the maestro of recombination. Cell 149: 257-259.
Symington, L.S. and Gautier, J. (2011) Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 45: 247-271.
Mott, C. and Symington, L.S. (2011) RAD51-independent inverted-repeat recombination by a strand-annealing mechanism. DNA Repair 10: 408-415.
Mimitou, E.P. and Symington, L.S. (2011) DNA end resection-unraveling the tail. DNA Repair 10: 344-348.
Ho, C.K., Mazon, G., Lam, A.F. and Symington, L.S. (2010) Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast. Mol. Cell 40: 988-1000.
Marrero, V.A. and Symington, L.S. (2010) Extensive DNA end processing by Exo1 and Sgs1 inhibits break-induced replication. PLoS Genetics 6: e1001007.
Mimitou, E.P. and Symington, L.S. (2010) Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO Journal 29: 3358-3369.
Smith, C.E., Lam, A.F. and Symington, L.S. (2009) Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase δ complex. Mol. Cell. Biol. 29: 1432-1441.
Fung, C.W., Mozlin, A.M. and Symington, L.S. (2009) Suppression of the double-strand break repair defect of the Saccharomyces cerevisiae rad57 mutant. Genetics 181: 1195-1206.
Mimitou, E.P. and Symington, L.S. (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774.
Mozlin, A.M., Fung, C.W. and Symington, L.S. (2008) Role of the Saccharomyces cerevisiae Rad51 paralogs in sister-chromatid recombination. Genetics 178: 113-126.
Smith, C.E., Llorente, B and Symington, L.S. (2007) Template switching during break-induced replication. Nature 447: 102-105.